Research progress on genetic susceptibility to thrombotic non-cirrhotic portal hypertension
10.3969/j.issn.1673-4130.2024.19.001
- VernacularTitle:血栓性非硬化门脉高压症的遗传易感性研究进展
- Author:
Wenxia MA
1
;
Zilong HE
;
Huiguo DING
;
Lingna LYU
Author Information
1. 首都医科大学附属北京佑安医院肝病消化中心/首都医科大学基础临床联合实验室,北京 100069
- Keywords:
non-cirrhotic portal hypertension;
portal vein thrombosis;
budd-chiari syndrome;
genetic susceptibility
- From:
International Journal of Laboratory Medicine
2024;45(19):2305-2310
- CountryChina
- Language:Chinese
-
Abstract:
Extrahepatic non-cirrhotic portal hypertension(NH-PH),a disease of portal hypertension repre-sented by extrahepatic non-cirrhotic portal vein thrombosis and budd-chiari syndrome,both of which are caused by splanchnic vein thrombosis and share a variety of common genetic susceptibility factors.The review summarized the research progress on genetic susceptibility to thrombotic NH-PH in recent decades,collating the reported genetic susceptibility genes and their mutation loci,as well as suggesting other potential gene tar-gets.The results of the study provided screening targets for subsequent large-sample validation in clinic,and delivered new ideas for the development of early diagnostic methods and pathogenesis of NH-PH.
