Research progress on the treatment of Candida albicans infection by metal nanoparticles
10.3969/j.issn.1673-4130.2024.18.014
- VernacularTitle:金属纳米颗粒治疗白念珠菌感染研究进展
- Author:
Aiqiong ZHOU
1
;
Wenjing DING
;
Wei QU
;
Fei MO
Author Information
1. 贵州医科大学医学检验学院,贵州贵阳 550000
- Keywords:
metal nanoparticles;
antifungal agent;
Candida albicans
- From:
International Journal of Laboratory Medicine
2024;45(18):2250-2257,2263
- CountryChina
- Language:Chinese
-
Abstract:
Candidiasis has a high morbidity and mortality worldwide,and its main causative agent is Candi-da albicans.At present,the treatment effect of candidiasis is not ideal due to the shortcomings of antifungal drugs,such as toxicity,drug resistance,single route of administration,and high price.In order to overcome this situation,metal nanoparticles with antifungal activity and the potential to deliver antifungal drugs have been extensively studied.In this paper,the mechanism and application of gold,silver,copper and iron nanoparticles against Candida albicans are reviewed.Compared with traditional antifungal drugs,metal nanoparticles exert antifungal effects through a multi-target mechanism,which minimizes the emergence of antifungal resistance.Cytotoxicity limits the application of metal nanoparticles,but green synthesis can reduce the cytotoxicity of metal nanoparticles and improve antimicrobial properties.
