Research progress of Alzheimer's disease and intestinal microecology
10.3969/j.issn.1673-4130.2024.18.013
- VernacularTitle:阿尔茨海默病与肠道微生态研究进展
- Author:
Yujian FAN
1
;
Jing LIU
;
Peichang WANG
;
Jingrong CAO
Author Information
1. 首都医科大学宣武医院检验科,北京 100053
- Keywords:
gut microbiota;
Alzheimer's disease;
β-amyloid protein;
gut-brain axis;
neuroinflam-mation;
blood-brain barrier
- From:
International Journal of Laboratory Medicine
2024;45(18):2244-2249
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is one of the most common types of dementia in clinical practice.The increased permeability of the gut and blood-brain barrier caused by intestinal microecological dysbiosis may be an important incentive to affect the incidence of AD.Gut microbiota regulates the central nervous system through the gut microbiota-gut-brain axis(gut-brain axis),and plays an important role in the cognitive func-tion,occurrence and development of clinical symptoms in AD patients.This review comprehensively reviewed the current literature on the relationship between gut microbiota dysregulation and inflammatory cytokine changes in AD,and the treatment of AD targeting with gut microbiota,so as to clarify the new progress in the influence of intestinal microecology changes on the cognitive function of AD patients,the potential diagnosis in the early onset of AD,and the potential mechanism of gut microbiota participating in the regulation of AD.It provides a new idea for the treatment strategy of AD.
