Effect of interaction between serum NGAL and complications after PCI on poor prognosis in STEMI patients
10.3969/j.issn.1673-4130.2024.18.011
- VernacularTitle:STEMI患者血清NGAL与PCI术后并发症的交互作用及对预后不良的影响
- Author:
Xiaodong ZHAO
1
;
Jianyu SHU
;
Rongrong ZHAO
;
Jianyun MAO
;
Bin LIU
Author Information
1. 张家口市第一医院心血管内科,河北张家口 075000
- Keywords:
ST-segment elevation myocardial infarction;
neutrophil gelatinase-associated lipid carrier protein;
percutaneous coronary intervention;
interaction;
prognosis
- From:
International Journal of Laboratory Medicine
2024;45(18):2234-2239
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of interaction between serum neutrophil gelatinase-associat-ed lipid carrier protein(NGAL)and complications after percutaneous coronary intervention(PCI)on poor prognosis in patients with ST-segment elevation myocardial infarction(STEMI),and to provide reference for improving prognosis.Methods From January 2017 to January 2020,a total of 400 STEMI patients admitted to this hospital were selected and divided into good prognosis group(n=378)and poor prognosis group(n=22)according to their 2-year prognosis.Logistic regression equations were used to analyze the prognostic fac-tors of STEMI patients,and multiplicative and additive effects were established to analyze the effect of the in-teraction between serum NGAL and post-PCI complications on poor prognosis.Results Gender,age,heart rate,Gensini score,number of lesions ≥2,Killip grade,complications after PCI and NGAL level after PCI were associated with poor prognosis in STEMI patients(P＜0.05).Gender(female),age,heart rate,Gensini score,number of lesions ≥2,Killip grade,complications after PCI and NGAL level after PCI were all inde-pendent influencing factors of poor prognosis in STEMI patients(P＜0.05).There was interaction between serum NGAL after PCI and complications after PCI,both of which had an adverse effect on the prognosis of STEMI patients(P＜0.05).There was no multiplicative interaction between serum NGAL and complications after PCI(P＞0.05).When serum NGAL and complications after PCI were exposed at the same time,the risk of poor prognosis in STEMI patients was higher than the sum of the two exposures alone,and the interaction was 2.611 times the sum of the effects of the two exposures alone.Conclusion Serum NGAL and postopera-tive complications after PCI are independent factors influencing poor prognosis in STEMI patients.There is a additive interaction between the two factors,and exposure can increase the risk of poor prognosis.
