Relationship between serum HMGB1,GP73,IL-37 and HBV-DNA load in patients with HBV-ACLF and their prognostic value
10.3969/j.issn.1673-4130.2024.18.006
- VernacularTitle:血清HMGB1、GP73、IL-37与HBV-ACLF患者HBV-DNA载量的关系及对预后的预测价值
- Author:
Xiuhong LIU
1
;
Qingling SONG
;
Miao GUO
;
Cong WANG
;
Daxin LEI
Author Information
1. 中国人民解放军联勤保障部队第九八○医院检验科,河北石家庄 050000
- Keywords:
chronic acute liver failure;
hepatitis B virus;
high mobility group protein B1;
Golgi pro-tein 73;
interleukin-37;
HBV-DNA load
- From:
International Journal of Laboratory Medicine
2024;45(18):2207-2212
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum high mobility group protein B1(HMGB1),Golgi protein 73(GP73),interleukin-37(IL-37)and HBV-DNA load in patients with hepatitis B virus-associated chronic plus acute liver failure(HBV-ACLF)and the value of predicting prognosis.Methods A total of 112 HBV-ACLF patients from the 980th Hospital of PLA Joint Logistic Support Force from July 2018 to July 2023 were retrospectively analyzed,and were divided into death group(n=42)and sur-vival group(n=70)according to the clinical outcomes of HBV-CALF patients within 90 days after admis-sion.The clinical data and serum levels of HMGB1,GP73 and IL-37 of the two groups were compared,the prognotic factors of the HBV-CALF patient were analyzed,and the relationship between serum HMGB1,GP73 and IL-37 and HBV-DNA load was analyzed.The prognostic value of serum HMGB1,GP73 and IL-37 in HBV-CALF patients were evaluated.Results There were significant differences in disease stage,peritonitis,hepatic encephalopathy,pulmonary infection,HBV-DNA load and MELD score between the death group and the survival group(P＜0.05).Serum levels of HMGB1,GP73 and IL-37 in death group were higher than those in survival group(P＜0.05).Disease stage,peritonitis,hepatic encephalopathy,pulmonary infection,HBV-DNA load,MELD score and serum HMGB1,GP73 and IL-37 levels were all independent prognoses of HBV-ACLF patients(P＜0.05).The levels of serum HMGB1,GP73 and IL-37 in HBV-ACLF patients were negatively correlated with HBV-DNA load(P＜0.05).The area under the curve(AUC)values of serum HMGB1,GP73 and IL-37 in predicting the prognosis of HBV-ACLF patients were 0.781,0.790 and 0.782,re-spectively.The AUC value of the combined prediction was the largest(0.944),and the sensitivity and speci-ficity were 86.33％and 91.43％,respectively.Conclusion Serum HMGB1,GP73 and IL-37 levels are closely related to HBV-DNA load and prognosis of HBV-CALF patients,and the combined detection of these three indexes is helpful to improve prognosis prediction efficiency.
