Application value of liver,renal function and autoantibody-related indexes in the diagnosis of neuromyelitis optica spectrum disorder
10.3969/j.issn.1673-4130.2024.18.003
- VernacularTitle:肝、肾功能及免疫相关指标在视神经脊髓炎谱系疾病诊断中的应用价值
- Author:
Yanan LIU
1
,
2
;
Wencan JIANG
;
Kelin CHEN
;
Chunqing SHAO
;
Xuesong LIU
;
Guojun ZHANG
Author Information
1. 首都医科大学附属北京天坛医院实验诊断中心,北京 100070
2. 北京市免疫试剂临床工程技术研究中心,北京 100070
- Keywords:
neuromyelitis optica spectrum disease;
liver function indexes;
renal function indexes;
au-toantibody-related indexes
- From:
International Journal of Laboratory Medicine
2024;45(18):2189-2196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the distribution characteristics and application value of liver,renal func-tion indexes and autoantibody-related indexes of neuromyelitis optica spectrum disorder(NMOSD).Methods The liver,renal function and autoantibody-related indexes data of patients diagnosed with NMOSD and multiple sclerosis(MS)in Beijing Tiantan Hospita,Capital Medical University from June 2015 to June 2023,as well as gender and age-matched controls underwent routine physical examination were retrospectively collected.A total of 95 patients with NMOSD(NMOSD group),230 patients with MS(MS group),and 244 healthy controls(routine physical examination group)were selected to evaluate the diagnostic value of each index for NMOSD.Results Compared with MS group,the levels of alanine aminotransferase,as well as the positive rates of α-hydroxybutyrate dehydrogenase,y-glutamyltransferase,anti-SS-A antibody,anti-SS-B anti-body,anti-ribosomal P protein antibody and Ro-52 antibody were significantly increased in NMOSD group,while the levels of albumin,indirect bilirubin and total bilirubin were significantly decreased,and the differ-ences were statistically significant(P＜0.05).The difference index between NMOSD and conventional physi-cal examination group was similar to that of MS group.The seven indexes,a-hydroxybutyrate dehydrogenase,albumin,globulin,direct bilirubin,indirect bilirubin,total bile acid and uric acid alkalinity could be used for the diagnosis of NMOSD.The area under the curve of combined diagnosis of NMOSD was 0.969,and the sensitiv-ity and specificity were 92.6％and 92.9％.Conclusion Multiple indexes of liver and kidney function in NMOSD patients are different from those in MS patients and healthy subjects underwent routine physical ex-amination,and the positive rate of some autoantibody indexes in NMOSD patients is higher than that in MS patients.Liver,renal function and autoantibody-related indexes can be used clinically to assist diagnosis,and the combined application of multiple indexes can further enhance its diagnostic value.
