Prognostic value of serum miRNA-21-5p and miRNA-5189-5p expression levels in elderly patients with prostate cancer after radical prostatectomy
10.3969/j.issn.1673-4130.2024.17.013
- VernacularTitle:血清miRNA-21-5p、miRNA-5189-5p表达水平对行根治性前列腺切除术老年前列腺癌患者预后的评估价值
- Author:
Hongxia FU
1
;
Zhiyan ZHOU
;
Shengxing WANG
;
Yinan HAN
Author Information
1. 海南医学院第一附属医院泌尿外科,海南海口 570102
- Keywords:
miRNA-21-5p;
miRNA-5189-5p;
prostate cancer;
radical prostatectomy;
prognosis;
prediction model
- From:
International Journal of Laboratory Medicine
2024;45(17):2113-2116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the prognostic value of serum microRNA(miRNA)-21-5p and miRNA-5189-5p expression levels in elderly patients with prostate cancer after laparoscopic radical prostatectomy(LRP).Methods A total of 213 elderly prostate cancer patients treated with LRP from January 2014 to Sep-tember 2018 in the First Affiliated Hospital of Hainan Medical College were retrospectively selected as the study objects.According to the 5-year follow-up outcome,the patients were divided into good prognosis group(87 cases)and poor prognosis group(126 cases).The preoperative clinical baseline data and the expression levels of serum miRNA-21-5p and miRNA-5189-5p were collected.Logistic regression analysis was used to screen the factors affecting the prognosis of patients.The prognostic prediction model was constructed with independent risk factors,and the predictive value was analyzed by drawing receiver operating characteristic(ROC)curve.Results Multivariate Logistic regression analysis showed that serum prostate specific antigen(PSA)level,positive incisal margin,and expression levels of miRNA-21-5p and miRNA-5189-5p were inde-pendent risk factors for the prognosis of elderly prostate cancer patients receiving LRP(P＜0.05).The com-bined prediction model was established based on independent risk factors,and the area under the curve of each factor alone predicting prognosis of elderly prostate cancer patients receiving LRP was less than that of four combined prediction(P＜0.05).Conclusion The expression levels of serum miRNA-21-5p and miRNA-5189-5p are of high value in predicting the prognosis of elderly prostate cancer patients after LRP.
