Predictive value of serum sOSCAR for cardiovascular adverse events after PCI in patients with acute non-ST segment elevation acute myocardial infarction
10.3969/j.issn.1673-4130.2024.17.012
- VernacularTitle:血清sOSCAR对急性非ST段抬高型急性心肌梗死患者PCI术后心血管不良事件的预测价值
- Author:
Wenchao MA
1
;
Kun WANG
;
Xiaolong WANG
;
Decheng XIE
;
Lei LIU
;
Sheng SUN
;
Fangcheng SU
Author Information
1. 潍坊市人民医院急诊内科,山东潍坊 261000
- Keywords:
acute non-ST segment elevation myocardial infarction;
angiopoietin-2;
soluble osteoclast-related receptor;
percutaneous coronary intervention;
prognosis
- From:
International Journal of Laboratory Medicine
2024;45(17):2108-2112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of serum soluble osteoclast-associated receptor(sOSCAR)for cardiovascular adverse events after percutaneous coronary intervention(PCI)in patients with acute non-ST segment elevation acute myocardial infarction(NSTEMI).Methods From January 2020 to Jan-uary 2022,124 NSTEMI patients admitted to Weifang People's Hospital who underwent PCI were selected as the NSTEMI group,and another 100 healthy volunteers in the same period were selected as the control group.The NSTEMI patients were classified into 31 cases of poor prognosis and 93 cases of good prognosis group ac-cording to whether major adverse cardiovascular events occurred 1 year after PCI.Multivariate Logistic regres-sion model was constructed to analyze the factors affecting the prognosis of NSTEMI patients after PCI,and receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of sOSCAR level on the prognosis of NSTEMI patients after PCI.Results Compared with the control group,serum angiopoietin-2(Ang-2)levels were increased and sOSCAR levels were decreased in the NSTEMI group(P＜0.05).At 1-year follow-up,the incidence of poor prognosis after PCI in 124 NSTEMI patients was 25.00％(31/124).Multivariate Logistic regression analysis showed that increasing age and Ang-2 were independent risk factors affecting the prognosis after PCI in patients with NSTEMI(P＜0.05),and elevated left ventricular ejection fraction and elevated sOSCAR were independent protective factors(P＜0.05).ROC curve analysis showed that the area under the curve of serum Ang-2 and sOSCAR levels combined to predict the prognosis after PCI in NSTEMI patients was 0.865,which was greater than that of serum Ang-2 and sOSCAR levels alone,which were 0.791 and 0.786(P＜0.05).Conclusion Serum sOSCAR level is decreased in patients with NSTEMI and is closely related to the poor prognosis of patients after PCI.Serum sOSCAR combined with Ang-2 has a high predictive value for the poor prognosis of NSTEMI patients after PCI.
