Expression of OTUD3,ILF2 in esophageal squamous cell cancer tissue and their relationship with clinical pathological characteristics and prognosis
10.3969/j.issn.1673-4130.2024.17.010
- VernacularTitle:食管鳞癌组织OTUD3和ILF2表达与临床病理特征及预后的关系
- Author:
Huijuan YU
1
,
2
;
Yong XIN
;
Hongying YIN
;
Jiasheng ZHAO
;
Li LI
Author Information
1. 徐州医科大学第一临床医学院,江苏徐州 221000
2. 淮安市第五人民医院肿瘤科,江苏淮安 223300
- Keywords:
esophageal squamous cell cancer;
OTU deubiquitinase 3;
interleukin enhancer binding fac-tor 2;
prognosis
- From:
International Journal of Laboratory Medicine
2024;45(17):2098-2102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of OTU deubiquitinase 3(OTUD3)and interleukin en-hancer binding factor 2(ILF2)in esophageal squamous cell cancer and their correlation with clinicopathologi-cal characteristics and prognosis.Methods A total of 102 patients with esophageal squamous cell cancer who underwent radical resection in Huai'an Fifth People's Hospital between January 2019 and July 2020 were in-cluded in this study.Immunohistochemistry was used to detect OTUD3 and ILF2 expression.Spearman rank correlation analysis was conducted to assess the relationship between OTUD3 and ILF2.Kaplan-Meier surviv-al curves were used to analyze the impact of OTUD3 and ILF2 expression on patient survival prognosis.COX regression analysis was employed to identify prognostic factors.Results Compared with adjacent tissues,the positive rate of OTUD3 was lower and the positive rate of ILF2 was higher in esophageal squamous cell cancer tissues,and the differences were statistically significant(P＜0.05).A significant negative correlation was ob-served between the expression of OTUD3 and ILF2 in esophageal squamous cell cancer(r=-0.712,P＜0.001).Furthermore,patients with TNM stage Ⅲ,low differentiation,and lymph node metastasis exhibited a lower positive rate of OTUD3 and a higher positive rate of ILF2 compared to patients with TNM stage Ⅰ-Ⅱ,medium-high differentiation,and no lymph node metastasis(P＜0.05).The 3-year survival rate for the OTUD3-positive group was significantly higher than that of the OTUD3-negative group(Log-rank x2=5.869,P=0.015).The 3-year survival rate for the ILF2-positive group was significantly lower than that of the ILF2-negative group(Log-rank x2=16.257,P＜0.001).TNM staging,lymph node metastasis,degree of differentiation,OTUD3,and ILF2 were independent factors affecting the prognosis of esophageal squamous cell cancer patients.Conclusion Decreased expression of OTUD3 and increased expression of ILF2 in esopha-geal squamous cell cancer tissues are implicated in the malignant progression of esophageal squamous cell cancer and serve as independent factors affecting patient outcomes.
