Establishment and verification of TSH reference interval for population in Pidu District of Chengdu
10.3969/j.issn.1673-4130.2024.17.009
- VernacularTitle:成都市郫都区人群TSH参考区间的建立及验证
- Author:
Yan ZHANG
1
,
2
;
Zhenzhen ZHAO
;
Binwu YING
Author Information
1. 四川大学华西医院实验医学科,四川成都 610041
2. 成都市郫都区中医医院检验科,四川成都 611730
- Keywords:
thyroid-stimulating hormone;
reference interval;
indirect method;
age;
gender
- From:
International Journal of Laboratory Medicine
2024;45(17):2092-2097
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish sex-and age-specific reference interval of thyroid stimulating hormone(TSH)for the population in Pidu District of Chengdu by an indirect method.Methods Data that did not meet the screening criteria were excluded.The TSH data of 37 514 patients from Traditional Chinese Medicine Hos-pital of Pidu District from March 2022 to August 2023 were collected.The data were deleted according to the screening criteria.The skewness-kurtosis method was used to test the normality,and the Turkey method was used to eliminate the outliers.The TSH levels of different genders and ages were compared by Mann-Whitney U test and Kruskal-Wallis H test,respectively.Non-parametric methods were used to calculate TSH reference interval.Its reliability was verified by two methods:when the relative deviation from the reference interval of the reagent specification was less than the reference change value(RCV)or more than 90％of the TSH result was within the reference interval,the result were proved to be reliable.Results A total of 25 761 valid TSH data were included,9 363 men and 16 398 women.They were divided into 8 subgroups according to age:10-＜18,18-30,＞30-40,＞40-50,＞50-60,＞60-70,＞70-80,＞80-90.Male TSH reference interval is 0.457-4.884,0.465-4.229,0.445-4.918,0.457-4.826,0.471-5.160,0.425-5.477,0.456-5.645,0.465-6.418 pIU/mL,respectively.The reference range of female TSH was 0.546-5.196,0.592-5.499,0.606-5.815,0.549-5.915,0.527-6.099,0.457-5.927,0.435-6.078,0.415-6.321 pIU/mL.The rela-tive deviations between the upper limit and lower limit of the reference interval and the reagent specification were smaller than the RCV(49.85％).When used to validate the population,each group had more than 90％TSH results in the reference interval.Conclusion A gender-and age-specific TSH reference interval is estab-lished by indirect method using big data,which can provide reference for accurate diagnosis and treatment of thyroid diseases.
