Application value of common clinical laboratory indicators in the diagnosis of myasthenia gravis
10.3969/j.issn.1673-4130.2024.17.008
- VernacularTitle:临床实验室常见指标在重症肌无力诊断中的应用价值
- Author:
Xuesong LIU
1
,
2
;
Wencan JIANG
;
Yanan LIU
;
Qisen XIAO
;
Xuan LIU
;
Yanfang ZHANG
;
Ping HAN
;
Guojun ZHANG
Author Information
1. 首都医科大学附属北京天坛医院实验诊断中心,北京 100070
2. 国家药监局体外诊断试剂质量控制重点实验室,北京 100070
- Keywords:
myasthenia gravis;
laboratory indicators;
diagnostic model
- From:
International Journal of Laboratory Medicine
2024;45(17):2087-2091,2097
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the basic case data and laboratory test index characteristics of patients with myasthenia gravis(MG),so as to evaluate the application value of common clinical laboratory indicators in the construction of a diagnostic model for MG.Methods A retrospective analysis was performed on the basic data and laboratory indicators of MG patients and gender and age-matched healthy controls diagnosed at Beijing Tiantan Hospital,Capital Medical University from April 2021 to April 2023.A diagnostic model was constructed,and the receiver operating characteristic(ROC)curve was drawn to analyze the area under the curve(AUC).Results The BMI,heart rate,systolic blood pressure,and diastolic blood pressure in the MG group were significantly higher than those in the control group,with statistical significance(P＜0.05).There were significant differences in total protein,albumin,white blood cell count,proportion of large platelets,abso-lute value of monocyte and triiodothyronine between MG group and control group(P＜0.05).Seven indexes of heart rate,diastolic blood pressure,albumin,creatine kinase,cholinesterase,triglyceride and apolipoprotein B were selected to construct the diagnostic model.The area under the curve of the combined application of multiple indexes could reach 0.995,with a sensitivity and specificity of 97.60％and 96.10％,respectively.Conclusion In this study,the laboratory test indexes that can be used for the diagnosis of MG are successfully selected,and the sensitivity and specificity of the combined application of multiple indexes are high,which can be used for the auxiliary diagnosis of MG.
