Research progress of T-cell subsets in regulating atherosclerosis
10.3969/j.issn.1673-4130.2024.16.023
- VernacularTitle:T细胞亚群在调控动脉粥样硬化中的研究进展
- Author:
Pengli HAI
1
;
Yucheng LI
;
Nan YANG
;
Chenwei LI
;
Li XU
Author Information
1. 吉林大学白求恩第二医院检验科,吉林长春 130022
- Keywords:
atherosclerosis;
T-cell subsets;
cytokines
- From:
International Journal of Laboratory Medicine
2024;45(16):2044-2048
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a chronic inflammatory disease characterized by autoimmune component,ser-ving as a primary factor in cardiovascular diseases.The atherosclerotic plaques involve a variety of immune cells which mediated complex immune and inflammatory responses at each stage of the disease's progression.Notably,within atherosclerotic plaques,T-cells,as the predominant immune cells,can be differentiated into various subsets with distinct functions.These T-cell subsets modulate the progression of atherosclerosis by se-creting either pro-inflammatory or anti-inflammatory cytokines.Understanding the impact of these immune cells on the disease's development is imperative for formulating novel therapeutic strategies.This article aims to review the roles of T-cell subsets and their secreted cytokines in atherosclerosis,aiming to offer new in-sights for the scientific research and clinical management of this condition.
