Application value of combined detection of serum NGAL and calprotectin in patients with fracture in early infection after joint replacement surgery
10.3969/j.issn.1673-4130.2024.16.019
- VernacularTitle:骨折患者血清NGAL、钙卫蛋白联合检测在骨关节置换术后早期感染中的应用价值
- Author:
Wei SONG
1
;
Yongdong WU
;
Shaofeng LI
;
Limei LIANG
Author Information
1. 张家口市第一医院骨一科,河北张家口 075000
- Keywords:
neutrophil gelatinase-associated lipocalin;
calprotectin;
fracture;
joint replacement sur-gery;
early infection
- From:
International Journal of Laboratory Medicine
2024;45(16):2023-2027
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value of combined detection of serum neutrophil gelati-nase-associated lipocalin(NGAL)and calprotectin in patients with fracture in early infection after joint re-placement surgery.Methods A total of 206 fracture patients who underwent joint replacement surgery in a hospital from July 2021 to July 2022 were selected as the study objects,and divided into infection group(n=29)and non-infection group(n=177)according to whether infection occurred after joint replacement surgery.Serum NGAL and calprotectin levels were detected by enzyme-linked immunosorbent assay,and the influencing factors of infection after joint replacement surgery in fracture patients were analyzed by multivari-ate Logistic regression.The receiver operating characteristic curve was drawn to analyze the diagnostic efficacy of serum NGAL and calprotectin combined detection in early infection after joint replacement surgery in frac-ture patients.Results The proportion of diabetes mellitus and erythrocyte sedimentation rate(ESR)in infec-tion group were significantly higher than those in non-infection group,while albumin was significantly lower than that in non-infection group,with statistical significance(P＜0.05).The levels of serum NGAL and cal-protectin in postoperative infection group were significantly higher than those in postoperative non-infection group,with statistical significance(P＜0.05).Serum NGAL,calprotectin,ESR and diabetes mellitus were risk factors for early infection after joint replacement surgery,while serum albumin was protective factor(P＜0.05).The area under the curve for the diagnosis of early infection after joint replacement surgery in patients with fracture was 0.838,0.813 and 0.934,respectively,and the combination of serum NGAL,calprotectin,and both were superior to the diagnosis of serum NG AL and calprotectin alone(Z=2.720,2.357,P=0.007,0.018).Conclusion The combined detection of serum NGAL and calprotectin has better diagnostic efficacy for early infection after joint replacement surgery in fracture patients,and has certain application value for clinical prognosis.
