Study on the relationship between serum sST2,Hey,IL-33 levels and degree of coronary artery stenosis and MACE in patients with acute myocardial infarction
10.3969/j.issn.1673-4130.2024.16.014
- VernacularTitle:急性心肌梗死患者血清sST2、Hcy、IL-33水平与冠脉狭窄程度及MACE的关系研究
- Author:
Chen YANG
1
;
Bin MENG
;
Junzhong ZHOU
Author Information
1. 徐州医科大学附属医院检验科,江苏徐州 210002
- Keywords:
acute myocardial infarction;
serum soluble growth stimulating expression gene 2 protein;
homocysteine;
interleukin-33
- From:
International Journal of Laboratory Medicine
2024;45(16):1991-1995
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum soluble growth stimulating expression gene 2 protein(sST2),homocysteine(Hcy)and interleukin(IL)-33 levels and degree of coronary artery ste-nosis and major cardiovascular adverse events(MACE)in patients with acute myocardial infarction(AMI).Methods A total of 139 patients with AMI admitted to a hospital from May 2021 to May 2023 were retro-spectively selected and divided into a good prognosis group(54 cases)and a poor prognosis group(85 cases)according to the occurrence of MACE.Spearman correlation was used to analyze the relationship between ser-um sST2,Hey,IL-33 levels and the degree of coronary artery stenosis in AMI patients.Multivariate Logistic regression was used to analyze the influencing factors of MACE occurrence in patients,and receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value of serum sST2,Hcy and IL-33 levels for MACE occurrence in AMI patients.Results Serum levels of sST2,Hcy and IL-33 in the poor prognosis group were significantly higher than those in the good prognosis group,and the difference was statistically sig-nificant(P＜0.05).Serum levels of sST2,Hcy and IL-33 in patients with severe and moderate stenosis were significantly higher than those in patients with mild stenosis,and the difference was statistically significant(P＜0.05).Spearman correlation analysis showed that serum sST2,Hcy and IL-33 levels were positively cor-related with the degree of coronary artery stenosis(P＜0.05).Serum Hcy,sST2 and IL-33 are risk factors for MACE in AMI patients.ROC curve analysis showed that the area under the curve(AUC)of serum sST2,Hcy and IL-33 levels for predicting the occurrence of MACE in AMI patients was 0.838,0.726 and 0.800,and the sensitivity was 87.1％,80.0％and 84.7％,respectively.The specificity was 77.8％,68.5％and 77.8％,re-spectively.The AUC of the combined prediction value of MACE in AMI patients was 0.906,and the sensitivi-ty and specificity were 88.2％and 90.7％,respectively.Conclusion Serum sST2,Hcy and IL-33 levels have certain predictive value for MACE in patients with AMI.
