Predictive value and efficacy evaluation of plasma miR-132,miR-134 combined with miR-124 in patients with depression
10.3969/j.issn.1673-4130.2024.16.009
- VernacularTitle:血浆miR-132、miR-134联合miR-124对抑郁症患者的预测价值及疗效评估
- Author:
Wenpeng DENG
1
;
Haojun XIONG
;
Guangtao HU
;
Wenjing YU
;
Junjie FAN
;
Yupeng LONG
Author Information
1. 陆军第九五八医院检验与输血科,重庆 400020
- Keywords:
depression;
microRNA-132;
microRNA-134;
microRNA-124;
brain-derived neurotro-phic factor
- From:
International Journal of Laboratory Medicine
2024;45(16):1962-1965,1972
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value and efficacy evaluation of plasma microRNA(miR)-132,miR-134 combined with miR-124 in patients with depression.Methods A total of 75 patients diagnosed with depression in the psychiatric department of the hospital from June 2021 to July 2023 were selected as the study group,and 75 healthy subjects who underwent physical examination in the hospital during the same pe-riod were selected as the control group.The relative expression levels of miR-132,miR-134 and miR-124 in plasma of the two groups were detected.The levels of miR-132,miR-124,miR-134,brain-derived neurotrophic factor(BDNF).inflammatory factors[interleukin(IL)-6,IL-18,tumor necrosis factor-a(TNF-a)]were com-pared between the two groups before and after 8 weeks of treatment.Multiple linear regression analysis was used to construct a joint prediction model.The application value of plasma miR-132,miR-134,miR-124 and combined prediction in the diagnosis of depression was evaluated by receiver operating characteristic(ROC)curve.Results The relative expression levels of miR-132 and miR-124 in plasma of the study group were sig-nificantly higher than those of the control group,with statistical significance(P＜0.05).The relative expres-sion level of miR-134 in the study group was significantly lower than that in the control group,and the differ-ence was statistically significant(P＜0.05).ROC curve analysis showed that the area under the curve of plas-ma miR-132,miR-134,miR-124 and combined prediction of depression were 0.858 8,0.851 9,0.763 1 and 0.971 4,respectively.Compared with 8 weeks before treatment,plasma miR-132,miR-124,IL-6,IL-18 and TNF-a levels were significantly down-regulated,while plasma miR-134 and BDNF levels were significantly up-regulated after 8 weeks of treatment.Conclusion miR-132,miR-134 and miR-124 are closely related to the oc-currence of depression,and the combination of the three can be used to predict and early diagnose depression patients and evaluate the drug efficacy of depression patients.
