Relationship between androgen level and adverse pregnancy outcome of pregnant women at advanced maternal age
10.3969/j.issn.1673-4130.2024.16.001
- VernacularTitle:高龄孕妇雄激素水平与不良妊娠结局的关系
- Author:
Wenyi CHEN
1
;
Xuelei WU
;
Fengying LU
;
Ming ZHANG
;
Bin ZHANG
;
Bin YU
Author Information
1. 常州市妇幼保健院医学遗传科,江苏常州 213000
- Keywords:
pregnant women at advanced maternal age;
androgen;
total testosterone;
adverse preg-nancy outcome
- From:
International Journal of Laboratory Medicine
2024;45(16):1921-1924
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between androgen level and adverse pregnancy outcome of pregnant women at advanced maternal age.Methods A total of 192 pregnant women who were admitted to Changzhou Maternal and Child Health Care Hospital for delivery from May to October 2022 were selected as the study objects.According to guidelines for diagnosis and treatment of hypertensive disorder complicating pregnancy and maternal age,the study objects were divided into simple pregnant women at advanced maternal age group,pregnant women at advanced maternal age complicated with hypertensive disorder complicating pregnancy,healthy control group and age-appropriate pregnant women complicated with hypertensive disorder complicating pregnancy group.Serum levels of five androgens[total testosterone(TT),sex hormone binding globulin(SHBG),free testosterone index(FTI),dehydroepiandrosterone sulfate(DHEAS)and androstendi-one(A2)]in each group were detected by chemiluminescence method.Results Compared with the healthy control group,TT,A2,FTI were significantly increased and SHBG was significantly decreased in the age-ap-propriate pregnant women complicated with hypertensive disorder complicating pregnancy group,the level of DHEAS was decreased in the simple pregnant women at advanced maternal age group,and the differences were statistically significant(P＜0.05).Pearson correlation analysis showed that TT was negatively correla-ted with age(P＜0.05),positively correlated with systolic blood pressure,diastolic blood pressure and body mass index(P＜0.05),and had no correlation with offspring sex and offspring weight(P＞0.05).Multivari-ate Logistic regression analysis showed that TT and body mass index were independent risk factors for hyper-tensive disorder complicating pregnancy in pregnant women(P＜0.05).Conclusion The level of androgen in pregnant women at advanced maternal age is related to the occurrence of hypertensive disorder complicating pregnancy.
