Clinical significance of Endoglin in prostate cancer research
10.3969/j.issn.1673-4130.2024.15.017
- VernacularTitle:Endoglin在前列腺癌研究中的临床意义
- Author:
Hui YANG
1
;
Hongyi ZHANG
;
Huafeng LI
;
Ganggang ZHAO
Author Information
1. 西安医学院第一附属医院泌尿外科,陕西西安 710077
- Keywords:
prostate cancer;
Endoglin;
early diagnosis;
targeted therapy
- From:
International Journal of Laboratory Medicine
2024;45(15):1887-1890
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is one of the most common malignant tumors in male genitourinary system,and it is one of the main causes of male death in Europe and America.The incidence of prostate cancer in our coun-try is increasing,the key of treatment of prostate cancer is early diagnosis and early treatment.Endoglin also known as endothelial glycoprotein,is the most reliable marker of endothelial cell proliferation,which is over-expressed in neovascularization.Soluble Endoglin was found in the serum of tumor patients,which can be used as an auxiliary diagnosis.Inhibition of Endoglin receptor can inhibit the formation of tumor blood vessels,which provides a basis for targeted therapy.Microvessel density marked by Endoglin is of great significance in the clinical and pathological grading of solid tumors and can be used to evaluate the prognosis.This article re-views the role of Endoglin in the pathogenesis,diagnosis,treatment and prognosis of prostate cancer.
