Study on the value of serum OLFM-2,ET-1 and sTREM-1 in predicting vascular restenosis after stent implantation in patients with lower extremity arteriosclerosis obliterans
10.3969/j.issn.1673-4130.2024.15.010
- VernacularTitle:血清OLFM-2、ET-1、sTREM-1预测下肢动脉硬化闭塞症患者支架植入术后血管再发狭窄的价值研究
- Author:
Feipeng WEI
1
;
Guozhuang WANG
Author Information
1. 中国人民解放军空军军医大学第二附属医院介入疼痛科,陕西西安 710038
- Keywords:
olfactomedin-2;
endothelin-1;
soluble triggering receptor expressed on myeloid cells-1;
lower extremity arteriosclerosis obliterans;
vascular restenosis
- From:
International Journal of Laboratory Medicine
2024;45(15):1844-1848,1855
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of serum olfactomedin-2(OLFM-2),endothelin-1(ET-1)and soluble triggering receptor expressed on myeloid cells-1(sTREM-1)in predicting vascular restenosis after stent implantation in patients with lower extremity arteriosclerosis obliterans(LASO).Methods A total of 140 LASO patients who received stenting in the interventional pain department of a hospital from January 2017 to December 2019 were selected as the study subjects.Serum levels of OLFM-2,ET-1 and sTREM-1 were detected by enzyme-linked immunosorbent assay.The serum levels of OLFM-2,ET-1 and sTREM-1 in LASO patients were compared before and after treatment.Patients were followed up for 1 year and were divid-ed into restenosis group(n=58)and non-restenosis group(n=82)according to whether they had recurrent vascular stenosis after surgery.Receiver operating characteristic(ROC)curve and Logistic regression were used to analyze the predictive value of postoperative serum OLFM-2,ET-1,and sTREM-1 on vascular resteno-sis after stenting in LASO patients.Results The levels of OLFM-2,ET-1 and sTREM-1 in serum of LASO patients after treatment were significantly higher than those before treatment,and the difference was statisti-cally significant(P<0.05).The serum levels of OLFM-2,ET-1 and sTREM-1 in restenosis group were sig-nificantly different from those in non-restenosis group(P<0.05).ROC curve analysis results showed that the optimal critical values of postoperative serum OLFM-2,ET-1 and sTREM-1 to predict the recurrence of vascu-lar stenosis after stent implantation in LASO patients were 27.35 ng/mL,97.36 pg/mL and 317.30 ng/L,re-spectively.The area under the curve(AUC)was 0.823(95%CI:0.722-0.923,P<0.001),0.787(95%CI:0.679-0.897,P<0.001)and 0.799(95%CI:0.688-0.910,P<0.001),respectively,the combined detec-tion of the three could increase the AUC to 0.904(95%CI:0.831-0.977,P<0.001).In LASO patients,the long length of lower extremity artery lesions,complete occlusion of lower extremity artery,trans-atlantic in-ter-society consensus type C+D and postoperative serum OLFM-2,ET-1 and sTREM-1 levels were independent risk factors for restenosis after stent implantation in LASO patients(P<0.05).Conclusion Serum levels of OLFM-2,ET-1 and sTREM-1 are significantly increased in patients with vascular restenosis after stent implantation in LASO patients.Postoperative three combined detection of OLFM-2,ET-1,sTREM-1 has a high clinical value in the evaluation of vascular restenosis after stent implantation in LASO patients.