Expression of serum HOXC9 in patients with hepatocellular carcinoma and its prognostic value
10.3969/j.issn.1673-4130.2024.15.009
- VernacularTitle:血清HOXC9在肝细胞癌患者中的表达及其对预后的评估价值
- Author:
Yong ZHANG
1
,
2
;
Weibo BO
;
Kunping GUAN
Author Information
1. 山西医科大学第二临床医学院,山西太原 030000
2. 南京医科大学康达学院附属连云港东方医院检验科,江苏连云港 222042
- Keywords:
hepatocellular carcinoma;
homeobox C9;
prognosis
- From:
International Journal of Laboratory Medicine
2024;45(15):1839-1843
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of serum homeobox C9(HOXC9)in patients with hepatocellular carcinoma(HCC)and its prognostic value.Methods A total of 79 patients with HCC(HCC group)and 72 patients with benign liver disease(benign liver disease group)were selected as the study ob-jects from the Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University from March 2020 to February 2021.Another 75 healthy subjects in the same period were selected in a hospital as healthy control group.The serum HOXC9 level was detected by enzyme-linked immunosorbent assay and the serum alpha-fetoprotein(AFP)level was detected by chemiluminescence assay.The relationship between serum HOXC9 level and clinicopathological features of HCC patients was analyzed,and Kaplan-Meier survival curve was used to analyze the relationship between serum HOXC9 level and HCC prognosis,and the receiver operating characteristic curve was drawn to analyze the diagnostic efficacy.Results The levels of HOXC9 and AFP in HCC group were significantly higher than those in benign liver disease group and healthy control group,and the difference was statistically significant(P＜0.05).HOXC9 positive group was correlated with tumor differentiation,TNM stage,vascular invasion and lymph node metastasis(x2=4.521,3.526,2.758,3.787,all P＜0.05).The 3-year survival rate was 64.71％(44/68)in the HOXC9 positive group and 81.82％(9/11)in the HOXC9 negative group.Kaplan-Meier survival curve analysis showed that the 3-year survival rate of HOXC9 positive group was lower than that of HOXC9 negative group,and the prognosis of HOXC9 positive group was worse,the difference was statistically significant(x2=5.367,P＜0.05).Cox multivariate analysis showed that multiple lesions,vascular infiltration,TNM stage Ⅲ-Ⅳ stage and HOXC9≥100 mAU/mL were independent risk factors for poor prognosis in HCC patients.The area under the curve of HOXC9 and AFP combined detection was 0.946(95％CI:0.876-0.979),which was significantly higher than that of single detection,and the differences were statistically significant(Z=0.871,0.511,P＜0.05).Conclu-sion The detection of serum HOXC9 level is helpful to evaluate the prognosis of HCC patients,and can be used as a biomarker for the prognosis of HCC patients.
