Analysis of the relationship between serum survivin,ABCA1 and poor coronary collateral circulation in patients with single coronary artery occlusion in acute myocardial infarction
10.3969/j.issn.1673-4130.2024.15.004
- VernacularTitle:血清survivin、ABCA1与急性心肌梗死单支冠脉闭塞患者冠脉侧支循环不良的关系分析
- Author:
Lina LIU
1
;
Man ZHANG
;
Jing LIU
;
Huijuan QUAN
;
Jingzhi WANG
;
Yulin GAO
;
Sushuang NAN
Author Information
1. 邯郸市第一医院心内科,河北邯郸 056000
- Keywords:
acute myocardial infarction;
survivin;
adenosine triphosphate binding cassette transporter A1;
single coronary artery occlusion;
coronary collateral circulation
- From:
International Journal of Laboratory Medicine
2024;45(15):1811-1815
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum survivin,adenosine triphosphate bind-ing cassette transporter Al(ABCA1)and poor coronary collateral circulation(CCC)in patients with single coronary artery occlusion in acute myocardial infarction(AMI).Methods A total of 155 patients with single coronary artery occlusion in AMI admitted to Handan Fist Hospital from May 2021 to May 2023 were selected as the study objects,and were divided into poor CCC group(n=80)and good CCC group(n=75)according to their CCC status.Serum survivin and ABCA1 levels were compared between the two groups,univariate and multivariate Logistic regression models were used to analyze the influencing factors of poor CCC,and the effi-cacy of serum survivin and ABCA1 in predicting poor CCC was analyzed by receiver operating characteristic curve.Results Compared with good CCC group,serum survivin and ABCA1 in poor CCC group were signifi-cantly decreased,and the difference was statistically significant(P＜0.05).Compared with good CCC group,Gensini score,creatinine kinase isoenzyme-MB(CK-MB),Killip heart function grade≥Ⅱ and history of hy-pertension in poor CCC group were significantly increased,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression model showed that high Gensini score,high CK-MB,Killip heart function grade≥Ⅱ and history of hypertension were risk factors for poor CCC(P＜0.05),while high sur-vivin and high ABCA1 were protective factors(P＜0.05).The area under the curve,sensitivity and specificity of the two indexes combined to predict poor CCC were 0.949,90.70％and 92.52％,which were significantly better than the single detection.Conclusion Serum survivin and ABCA1 are closely relate to poor CCC in pa-tients with single coronary artery occlusion in AMI,the lower the serum levels of survivin and ABCA1,the greater the risk of poor CCC,the combine detection of the two has a high predictive value for poor CCC in pa-tients with single coronary artery occlusion in AMI.
