Investigation on the use of antiretroviral drugs therapy in anti-TP positive blood donor
10.3969/j.issn.1673-4130.2024.14.006
- VernacularTitle:抗-TP阳性献血者中抗病毒治疗药物使用情况分析
- Author:
Xiaoxuan XU
1
;
Rui ZHU
;
Aijia ZHANG
;
Yizhong LIU
;
Chenying QI
;
Tong LI
;
Tingting CHEN
;
Jinfeng ZENG
;
Lilin WANG
Author Information
1. 深圳市血液中心,广东深圳 518035
- Keywords:
voluntary blood donor;
antiretroviral therapy drugs;
treponema pallidum;
detection rate;
blood safety
- From:
International Journal of Laboratory Medicine
2024;45(14):1692-1698
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out the prevalence of antiretroviral therapy(ART)drugs among treponema pallidum(TP)antibody(anti-TP)positive blood donors in Shenzhen,and to assess the blood safety risks brought about by the new trends of human immunodeficiency virus(HIV)diagnosis and treatment.Methods A stratified random sampling method was used to select 60 repeat blood donors(negative control group)who passed blood screening in Shenzhen from March 2019 to January 2023,and 3 people who regularly took known ART drugs were named positive control group,358 anti-TP positive/anti-HIV negative blood do-nors were named experimental group 1,20 anti-TP positive/anti-HIV positive blood donors were named ex-perimental group 2.The liquid chromatography-mass spectrometry(HPLC-MS/MS)was applied to detect the concentration of 8 ART drugs in plasma samples of each group,and the use of ART drugs was analyzed.Re-sults After the positive control group's plasma was diluted with a 1:6 dilution mixture,the ART drugs could still be detected.The positive mixed plasma samples of 1:6 people in Group 1 and Group 2 were split and validation,one ART drug positive sample was detected in Group 2,which was positive for anti-HIV,pro-tein immunoblotting,and HIV RNA.The detection rate of ART drugs in anti-TP positive blood donors was 0.26％,0.00％in Group 1 and 4.00％in Group 2.Conclusion The use of ART drugs has been found among anti-TP positive blood donors in Shenzhen,and people with HIV infection and high-risk sexual behavior are more likely to use antiretroviral drugs.
