Application value of neutrophil to lymphocyte subsets ratios in clinical staging and pathological typing of non-small cell lung cancer
10.3969/j.issn.1673-4130.2024.14.003
- VernacularTitle:中性粒细胞与淋巴细胞亚群比值在非小细胞肺癌临床分期及病理分型中的应用价值研究
- Author:
Ligai ZHANG
1
;
Kai CHANG
;
Yu WU
;
Yu PEI
;
Yuan HE
Author Information
1. 陆军军医大学第一附属医院检验科,重庆 400038
- Keywords:
neutrophil to lymphocyte subsets ratios;
non-small cell lung cancer;
clinical staging;
pathological classification
- From:
International Journal of Laboratory Medicine
2024;45(14):1675-1681,1686
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value of neutrophil to lymphocyte subsets ratios in clinical staging and pathological classification of non-small cell lung cancer(NSCLC).Methods A total of 132 NSCLC patients who were hospitalized and diagnosed by histopathology from January 2018 to December 2020 in the hospital were selected as the NSCLC group.Another 85 healthy individuals who underwent physical ex-aminations at the same hospital were selected as the control group,and the neutrophil to lymphocyte subsets ratios of the two study groups were detected and calculated for comparison.Results Compared with the con-trol group,the CD3+T cell,CD4+T cell,CD8+T cell,B cell,natural killer(NK)cell,and CD4+/CD8+in the NSCLC group were significantly reduced,while neutrophil to lymphocyte ratio(NLR),neutrophil to CD3+T cell ratio(N/CD3+),neutrophil to CD4+T cell ratio(N/CD4+),neutrophil to CD8+T cell ratio(N/CD8+),neutrophil to B cell ratio(N/B),and neutrophil to NK cell ratio(N/NK)significantly increased(P＜0.05).Compared with adenocarcinoma group,NLR,N/CD3+,N/CD4+,N/B.and N/NK were higher in the squa-mous cell carcinoma group(P＜0.05).NLR,N/CD3+,N/CD4+,N/CD8+,N/B and N/NK in the stage Ⅰgroup,the stage Ⅱ group,the stage Ⅲ group and the stage Ⅳ group were significantly higher than those in the control group(P＜0.05).Compared with the stage Ⅰ group,N/CD3+,N/CD4+,N/CD8+,and N/B in the stage Ⅲ group and the stage Ⅳ group were significantly increased(P＜0.05),while CD3+T cell and B cell were significantly decreased(P＜0.05).Receiver operating characteristic curve results showed that the area under the curve and Youden index of the neutrophils to lymphocyte subsets ratios were higher than those of the corresponding lymphocyte subsets.The Linear Support Vector Classification(Linear SVC)algorithm based on machine learning was used to construct a NSCLC risk prediction model using N/CD3+,N/CD4+,N/CD8+,N/B,and N/NK indicators.The results showed that the area under the curve could reach 0.929,with a positive predictive value of 0.911 and a negative predictive value of 0.787.Conclusion The neutrophil to lym-phocyte subsets ratios are closely related to the clinical staging and pathological classification of NSCLC.The combined detection of N/CD3+,N/CD4+,N/CD8+,N/B,and N/NK has high clinical diagnostic efficacy and could provide new diagnostic and therapeutic ideas for the early diagnosis and assessment of the severity of NSCLC.
