Clinical value of serum lncRNA CBSLR and ITIH4 in the diagnosis of early gastric cancer in the elderly
10.3969/j.issn.1673-4130.2024.14.001
- VernacularTitle:血清lncRNA CBSLR及ITIH4检测在老年早期胃癌诊断中的临床价值
- Author:
Qinyan MA
1
;
Guoqing GU
;
Hui WANG
Author Information
1. 南京医科大学附属老年医院/江苏省老年病医院/江苏省省级机关医院/江苏省老年医学研究所消化内科,江苏南京 210000
- Keywords:
early gastric cancer;
long chain non coding RNA CBSLR;
α trypsin H4 heavy chain;
clin-ical and pathological characteristics;
diagnostic value
- From:
International Journal of Laboratory Medicine
2024;45(14):1665-1669,1674
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the diagnostic value of serum long chain non coding RNA(lncRNA)CB-SLR,α trypsin H4 heavy chain(ITIH4)in early gastric cancer in the elderly.Methods From 2020 to 2022,a total of 90 elderly patients with early gastric cancer diagnosed and treated in the hospital were selected as the early gastric cancer group,while 45 patients with chronic atrophic gastritis diagnosed and treated in the same period were selected as atrophic gastritis group and 45 healthy people undergoing physical examination in the same period were selected as the healthy control group.The serum levels of lncRNA CBSLR and ITIH4 in each group were detected by fluorescence quantitative PCR and enzyme linked immunosorbent assay.Pearson correlation analysis was performed to determine the correlation between serum lncRNA CBSLR and ITIH4 levels with tumor markers carcinoembryonic antigen(CEA)and carbohydrate antigen(CA)19-9.The levels of serum lncRNA CBSLR and ITIH4 among patients with different clinicopathological characteristics were com-pared.The diagnostic value of serum lncRNA CBSLR and ITIH4 in elderly patients with early gastric cancer was analyzed by receiver operating characteristic curve.Results The serum levels of lncRNA CBSLR,ITIH4,CEA and CA19-9 in the early gastric cancer group were significantly higher than those in the atrophic gastritis group and health control group(all P＜0.05).There was significant positive correlation between serum ln-cRNA CBSLR,ITIH4 and CEA,CA19-9 levels in patients with early gastric cancer(r=0.601-0.751,all P＜0.05).In patients with early gastric cancer,serum IncRNA CBSLR and ITIH4 were related to tumor diame-ter,depth of invasion,differentiation type,and lymph node metastasis(all P＜0.05),but not related to age,gender,tumor location,and gross type(all P＞0.05).The area under the curve of combined detection of ser-um lncRNA CBSLR,ITIH4,CEA and CA19-9(0.912,95％CI:0.858-0.949)for the diagnosis of early gas-tric cancer was higher than that of serum lncRNA CBSLR(0.833,95％CI:0.784-0.879),ITIH4(0.806,95％CI:0.760-0.847),CEA(0.791,95％CI:0.742-0.830),and CA19-9(0.766,95％CI:0.710-0.815)alone(Z=4.482,5.130,5.231,6.117,all P＜0.05).Conclusion The elevated levels of serum lncRNA CB-SLR and ITIH4 in elderly patients with early gastric cancer are associated with adverse clinicopathological characteristics of gastric cancer.The combination of serum lncRNA CBSLR,ITIH4,CEA and CA19-9 has high diagnostic value for elderly patients with early gastric cancer.
