Relationship between serum LXA4 and S100A4 levels and disease and disease outcome in children with primary nephrotic syndrome
10.3969/j.issn.1673-4130.2024.12.009
- VernacularTitle:原发性肾病综合征患儿血清LXA4、S100A4水平与病情、疾病转归的关系
- Author:
Wei XIA
1
;
Di TAO
;
Jiale ZHOU
;
Pei ZHANG
;
Zhongmin FAN
Author Information
1. 南京明基医院/南京医科大学附属明基医院儿肾科,江苏南京 210000
- Keywords:
primary nephrotic syndrome;
S100 calc-binding protein A4;
lipoxygenin A4;
prognosis
- From:
International Journal of Laboratory Medicine
2024;45(12):1453-1457
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum lipoxygenin A4(LXA4)and S100 calc-binding protein A4(S100A4)levels and disease and disease outcome in children with primary nephrotic syn-drome(PNS).Methods A total of 168 children with PNS admitted to Nanjing Mingji Hospital from March 2020 to March 2022 were selected as the study objects,and 150 healthy children who came to Nanjing Mingji Hospital for physical examination were selected as the control group.The children with PNS were divided into remission group(n=73)and attack group(n=95)according to disease activity.Serum LXA4 and S100A4 levels were detected by enzyme-linked immunosorbent assay.The patients were followed up for 1 year after discharge and were divided into good prognosis group(n=138)and poor prognosis group(n=30)according to the prognosis.Spearman correlation analysis was used to investigate the relationship between serum LXA4,S100A4 levels and disease activity.The predictive value of serum LXA4 and S100A4 in the prognosis of PNS children was evaluated by receiver operating characteristic(ROC)curve.Multivariate Logistic regression was used to analyze the prognostic factors of PNS children.Results The serum levels of LXA4 and S100A4 in the remission group and the attack group were higher than those in the control group,and the serum levels of LXA4 and S100A4 in the attack group were higher than those in the remission group(P＜0.05).The serum levels of LXA4 and S100A4 were positively correlated with disease activity in children with PNS(r=0.593,0.546,P＜0.05).The good prognosis group had significantly lower serum levels of LXA4 and S100A4 than the poor prognosis group(P＜0.05).The area under the curve(95％CI)of serum LXA4 and S100A4 for pre-dicting the outcome of PNS in children was 0.767(0.756-0.888)and 0.846(0.824-0.863),respectively.The area under the curve of the joint(95％CI)was 0.905(0.879-0.924).Compared with the good progno-sis group,the poor prognosis group had significantly higher proportion of nephritis type,24 h urinary protein,hematuria,and urine protein clearance time,and significantly lower proportion of simple type,total protein,and IgM levels(P＜0.05).The multivariate Logistic regression analysis showed that hematuria(OR=2.300,95％CI 1.598-3.312),24 h urinary protein 121.25 mg/24 h(OR=2.098,95％CI 1.489-2.956),LXA4≥95.64 ng/L(OR=2.627,95％CI 1.737-3.973),and S100A4≥248.15 ng/L(OR=2.729,95％CI 1.777-4.192)were risk factors for poor prognosis in children with PNS(P＜0.05).Conclusion The serum levels of S100A4 and LXA4 are increased in children with PNS,and are related to disease activity and progno-sis,which may be used as potential markers for evaluating the condition and prognosis of PNS.
