Predictive value of serum PTX3 and Sema4d for postoperative fracture recurrence in elderly patients with osteoporotic fracture
10.3969/j.issn.1673-4130.2024.11.013
- VernacularTitle:老年骨质疏松性骨折患者血清PTX3、Sema4d对术后骨折再发的预测价值
- Author:
Fulong GU
1
;
Jiang JIANG
;
Shuijie SHEN
;
Sheng WANG
Author Information
1. 南京中医药大学附属南通医院骨伤科,江苏南通 226001
- Keywords:
osteoporotic fracture;
pentraxin 3;
semaphorin 4D;
fractures recurrence
- From:
International Journal of Laboratory Medicine
2024;45(11):1343-1347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of pentraxin 3(PTX3)and semaphorin 4D(Sema4d)in serum for postoperative fracture recurrence in elderly patients with osteoporotic fracture(OPF).Methods A total of 168 elderly patients with OPF who were treated in this hospital from January 2022 to January 2023 were selected.According to the occurrence of postoperative fracture recurrence,the patients were divided into non-recurrence group(116 cases)and recurrence group(52 cases).The levels of PTX3 and Se-ma4d in serum were detected by enzyme-linked immunosorbent assay.The influencing factors of fracture re-currence were analyzed by multivariate Logistic regression,and the correlation between PTX3 level and Se-ma4d was analyzed by Pearson correlation.The receiver operating characteristic(ROC)curve was used to ana-lyze the predictive value of PTX3 and Sema4d levels for postoperative fracture recurrence,and Z test was used to compare the area under the curve(AUC).Results There were significant differences in nutritional defi-ciency,puncture site,bone mineral density T value,fracture degree and serum PTX3,Sema4d levels between recurrence group and non-recurrence group(P＜0.05).Bone mineral density T value was an independent pro-tective factor for postoperative fracture recurrence,and fracture degree,serum PTX3,Sema4d levels were in-dependent risk factors for postoperative fracture recurrence(P＜0.05).There was a positive correlation be-tween serum PTX3 and Sema4d in recurrence group(r=0.415,P＜0.001).The AUC of the combination of PTX3 and Sema4d in the diagnosis of postoperative fracture recurrence was 0.910(95％CI 0.857-0.949),which was better than that of serum PTX3 and Sema4d alone(Zcombination-PTX3=3.129,Zcombination-Sema4D=3.123,both P=0.002).Conclusion The serum levels of PTX3 and Sema4d are increased in elderly OPF patients with postoperative fracture recurrence.The combination of PTX3 and Sema4d has a high value in the diagnosis of postoperative fracture recurrence in elderly OPF patients,and can be used as an early diagnostic index.
