Correlation analysis between complement C3,C4,CRP,ESR and disease activity in systemic lupus erythematosus
10.3969/j.issn.1673-4130.2024.11.010
- VernacularTitle:补体C3、C4及CRP、ESR与系统性红斑狼疮疾病活动度的相关性分析
- Author:
Jinghong WANG
1
;
Lu PAN
;
Bingru LU
;
Shiyu ZHAO
;
Shan DING
;
Yiqing LIU
Author Information
1. 山东第一医科大学附属省立医院临床医学检验部,山东济南 250021
- Keywords:
complement C3;
complement C4;
erythrocyte sedimentation rate;
systemic lupus erythe-matosus
- From:
International Journal of Laboratory Medicine
2024;45(11):1327-1330,1337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between complement C3,C4,C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)and disease activity of systemic lupus erythematosus(SLE).Methods A total of 69 SLE patients admitted to the hospital from January to December 2021 were selected as the SLE group,and 70 healthy individuals were selected as the control group during the same period.The changes of serum related indicators were compared between the SLE group and the control group.According to systemic lupus erythematosus disease activity index(SLEDAI),SLE patients were divided into mild active group(27 cases)and moderate and severe active group(42 cases).The changes of related indicators were compared between the two groups.Spearman correlation analysis was used to analyze the correlation between SLEDAI score and serum related indicators.Receiver operating characteristic(ROC)curve was used to ana-lyze the validity of diagnosis of disease severity.Results Compared with the control group,the levels of serum complement C3 and C4 in the SLE group were decreased,and the levels of CRP and ESR were increased,the differences were statistically significant(P＜0.05).Compared with the mild group,the levels of serum com-plement C3 and C4 in the moderate and severe group were decreased,and the levels of CRP and ESR were in-creased,and the differences were statistically significant(P＜0.05).The SLEDAI score of SLE patients was positively correlated with serum CRP and ESR levels(P＜0.05),and negatively correlated with serum com-plement C3 and C4 levels(P＜0.05).The area under the curve(AUC)of CRP,ESR,complement C3 and C4 were 0.716,0.875,0.872 and 0.856,respectively,the sensitivity were 59.52％,85.71％,78.57％and 78.79％,respectively,and the specificity were 79.83％,81.67％,86.79％and 86.54％,respectively.Conclu-sion Serum complement C3,C4,CRP and ESR are correlated with the progression of SLE,and play auxiliary roles in the disease activity stage of SLE.
