Prognostic value of CDKN3 and analysis of immune cell infiltration in oral squamous cell carcinoma
10.3969/j.issn.1673-4130.2024.11.005
- VernacularTitle:CDKN3在口腔鳞状细胞癌中的预后价值及免疫细胞浸润分析
- Author:
Hui ZHU
1
;
Huanping LU
;
Tianyou LI
;
Jing CHEN
Author Information
1. 上海交通大学医学院附属第九人民医院检验科,上海 200011
- Keywords:
oral squamous cell carcinoma;
cyclin-dependent activator 3;
immune infiltration
- From:
International Journal of Laboratory Medicine
2024;45(11):1302-1307
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the predictive value of cyclin-dependent activator 3(CDKN3)in the prog-nosis of oral squamous cell carcinoma(OSCC)and its relationship with immune cell infiltration,and to ex-plore the biological function of CDKN3 in the occurrence and development of OSCC.Methods RNAseq data related to OSCC were obtained from the Cancer Genome Atlas and Gene Expression Omnibus database.The expression level of CDKN3,prognostic value,clinicopathological features and immune cell infiltration were an-alyzed by R language and statistical methods.Gene enrichment analysis was used to analyze the biological role of CDKN3 in OSCC.Results Compared with normal tissues,CDKN3 was highly expressed in OSCC tumor tissues(P＜0.01),and the area under curve for the receiver operating characteristic curve was 0.955.The pa-tients with high expression of CDKN3 had a poor prognosis(P=0.024).The expression of CDKN3 was cor-related with pathological stage(P＜0.05)and histological grade(P＜0.001).There was a significant differ-ence in the level of immune cell infiltration between the CDKN3 high and low expression groups(P＜0.05).Functional enrichment analysis showed that CDKN3 was closely related to cell cycle.Conclusion CDKN3 may be a potential carcinogenic risk factor of OSCC,which is related to the clinicopathological characteristics,prog-nosis and immune cell infiltration of patients.CDKN3 may be a diagnostic biomarker and a potential therapeu-tic target for OSCC.
