Study on genotype distribution of hepatitis B and C in Lanzhou
10.3969/j.issn.1673-4130.2024.11.002
- VernacularTitle:兰州地区乙型及丙型病毒性肝炎基因型分布研究
- Author:
Zejing LIU
1
;
Xinyue LIU
;
Xue WU
;
Shangdi ZHANG
Author Information
1. 兰州大学第二医院检验医学中心,甘肃兰州 730030
- Keywords:
hepatitis B virus;
hepatitis C virus;
genotype
- From:
International Journal of Laboratory Medicine
2024;45(11):1285-1288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genotype distribution characteristics of hepatitis B virus(HBV)and hepatitis C virus(HCV)in Lanzhou.Methods From January 2018 to August 2023,1 130 patients with HBV infection and 1 781 patients with HCV infection in the hospital were genotyped by PCR-fluorescent probe method.SPSS26.0 statistical software was used to analyze the data.Results Genotype C was the most common genotype(925 cases,82.0％),followed by genotype B(124 cases,11.0％).There was no significant difference in gender distribution among genotypes B,C and D(x2=3.66,P=0.09),but there was significant difference among different age groups(x2=33.88,P=0.01).Genotype 2a was the most common genotype(930 cases,52.2％),followed by genotype 1b(737 cases,41.4％).There was significant difference in gender distribution among different genotypes(x2=46.31,P=0.01).There were significant differences in the distri-bution of genotype 1b and 2a among different age groups(x2=18.36,P=0.01).Conclusion HBV C geno-type and HCV 2a genotype are the main infection genotypes in patients with viral hepatitis in Lanzhou.The distribution of HBV genotypes B,C and D was related to age.The distribution of HCV genotypes was related to gender,and the distribution of HCV 1b and 2a genotypes was different with age.
