Correlation analysis between cranial imaging changes and clinical indicators in newborns infected with human cytomegalovirus
10.3760/cma.j.issn.1673-4408.2024.09.011
- VernacularTitle:新生儿人巨细胞病毒感染头颅影像学改变与临床指标的相关性分析
- Author:
Shuang WANG
1
;
Fei ZOU
;
Zhengrong SUN
Author Information
1. 中国医科大学附属盛京医院人类遗传资源库，沈阳 110004
- Keywords:
Human cytomegalovirus;
Newborn;
Peripheral blood mononuclear cell;
Imaging;
Central nervous system injury
- From:
International Journal of Pediatrics
2024;51(9):628-633
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between cranial imaging changes and clinical detection indicators in newborns infected with human cytomegalovirus（HCMV），and to provide a basis for the assessment and monitoring of clinical HCMV infection.Methods:A total of 87 newborns with HCMV infection treated in Shengjing Hospital of China Medical University from August 2016 to December 2017 were selected.According to the cranial imaging examination results，they were divided into an abnormal group（25 cases）and a normal group（62 cases）.The HCMV-DNA copy number of peripheral blood mononuclear cell（PBMC）was detected by real time PCR，and the clinical data of two groups of newborns were analyzed.Logistic regression was used for multivariate analysis，and drawed receiver operating characteristic（ROC）curve to evaluate the predictive value of each indicator for cranial imaging examination results.Results:Compared with the normal group，the newborns in abnormal cranial imaging group had smaller gestational age（29.29w vs 33.00w， P=0.004），lower birth weight（1 393.00g vs 1 835.00g， P=0.003），lower hemoglobin levels（87.00 g/L vs 98.00 g/L， P=0.025），and significantly higher PBMC HCMV-DNA copy number（80.00% vs 51.61%， P=0.015），with statistically significant differences.The area under the ROC curve of the predictive value of PBMC HCMV-DNA quantitative detection for cranial imaging results was 0.671（ P=0.016），with high sensitivity compared with HCMV-IgM antibody and urinary HCMV-DNA quantification.Logistic regression analysis showed that there was a certain correlation between PBMC HCMV-DNA quantification，gender，and total bilirubin levels and changes in cranial imaging（ P<0.05）.Three indicators combined to predict the area under ROC curve of abnormal cranial imaging results was 0.860（95% CI：0.743~0.976）. Conclusion:PBMC HCMV-DNA quantitative detection has a certain correlation with the cranial imaging changes of newborns with symptomatic HCMV infection，which can provide a reference for risk assessment of nervous system injury.
