Progress of vitamin D and its receptor gene polymorphisms and kidney diseases
10.3760/cma.j.issn.1673-4408.2024.09.007
- VernacularTitle:维生素D及其受体基因多态性与肾脏疾病的研究进展
- Author:
Bin WANG
1
;
Lijun ZHAO
;
Zhaoyuan SU
Author Information
1. 山西医科大学儿科医学系，太原 030001
- Keywords:
Children;
Vitamin D;
Kidney disease;
Vitamin D receptor;
Genetic polymorphisms
- From:
International Journal of Pediatrics
2024;51(9):605-609
- CountryChina
- Language:Chinese
-
Abstract:
Vitamin D works in the active form 1，25（OH） 2D 3 after binding to vitamin D receptor.Vitamin D deficiency is common in children with renal disease，and the abnormalities of vitamin D and its metabolic pathways are closely related to the occurrence and development of proteinuria and the deterioration of renal function.Vitamin D not only plays its classic role in maintaining calcium and phosphorus homeostasis，but also protects the kidney by improving the immune function of children，blocking the renin-angiotensin-aldosterone system，preventing the occurrence and development of proteinuria，alleviating the damage of podocytes，and delaying renal interstitial fibrosis.Therefore，this article reviews the research progress of vitamin D and its receptor gene polymorphism and kidney disease，in order to serve the clinical practice.
