Advances in HMGB1 gene and childhood disease
10.3760/cma.j.issn.1673-4408.2024.08.013
- VernacularTitle:HMGB1基因与儿童疾病的研究进展
- Author:
Lirong BAN
1
;
Yanyan LIANG
;
Hua ZHU
Author Information
1. 内蒙古医科大学，呼和浩特 010020
- Keywords:
Children;
High mobility group box 1 protein;
HMGB1 gene
- From:
International Journal of Pediatrics
2024;51(8):563-566
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box 1 protein（HMGB1）gene is located on chromosome 13q12 and is widely expressed in various tissues and cells.The encoded non-histone chromosome binding protein regulates transcription and participates in DNA repair.It plays an important role in processes such as inflammation，cell differentiation and tumor cell migration，and has become a valuable biomarker in a variety of diseases. In recent years，more and more studies have found that this gene is closely related to various diseases in children，such as respiratory diseases，digestive diseases，autoimmune diseases，cardiovascular diseases and so on.This article reviews the research progress of HMGB1 gene in children ' s diseases.
