Mechanism of aerobic glycolysis in respiratory virus infection
10.3760/cma.j.issn.1673-4408.2024.08.011
- VernacularTitle:有氧糖酵解在呼吸道病毒感染中的作用机制
- Author:
Jinjia FANG
1
;
Gen LU
Author Information
1. 广州医科大学附属妇女儿童医疗中心呼吸科 510623
- Keywords:
Aerobic glycolysis;
Respiratory virus infection;
Immune response
- From:
International Journal of Pediatrics
2024;51(8):553-557
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory viruses constantly undergo adaptive changes in long-term competition with the host，and are now able to alter the host metabolism to promote their own replication.As an extremely important part of host cell metabolism，glucose metabolism is closely related to respiratory virus infections.It is known that respiratory viruses can activate aerobic glycolysis in host cells through a variety of mechanisms to rapidly generate ATP，lactate and a series of intermediate metabolites.On one hand，aerobic glycolysis can facilitate viral invasion，replication，and evasion of immune surveillance；on the other hand，it can modulate the functional activities of host immune cells，thereby maintaining immune homeostasis during the elimination of viruses.This shows that respiratory viruses compete with host immune cells for glucose，and the one with the competitive advantage can affect the prognosis and regression of the disease.Therefore，this paper mainly discusses the role of aerobic glycolysis in the pathogenesis of respiratory virus infections，to provide new ideas for the fight against respiratory virus infections.
