Progress on the mechanism and treatment of steroid-resistant nephrotic syndrome in children induced by TRPC6 gene variation

VernacularTitle:TRPC6基因变异致儿童激素耐药型肾病综合征的机制及其治疗研究进展
Author: Gongping ZHAO ¹ ; Jitong LI ; Cuihua LIU
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1. 郑州大学附属儿童医院　河南省儿童医院　郑州儿童医院肾脏风湿科　郑州市儿童肾脏病研究重点实验室　450018
Keywords: Children; Gene of TRPC6; Variation of gene; Nephrotic syndrome
From: International Journal of Pediatrics 2024;51(8):532-536
CountryChina
Language:Chinese
Abstract: Transient receptor potential cation channel 6（TRPC6）gene is mainly expressed in renal podiocytes.Its variation can lead to steroid-resistant nephrotic syndrome（SRNS），and the specific pathogenesis is not clear.These children have poor response to hormones and immunosuppressants，with lack of specific therapeutic drugs，and poor prognosis.In recent years，it has been found that some drugs can slow down disease progression by inhibiting the expression of TRPC6 gene or its downstream signaling pathway，and the discovery of TRPC6 protein-specific blockers may be the hope of treating such children.This review focuses on the pathogenesis of SRNS induced by TRPC6 gene variation in children and the research progress of drug therapy.