Advances in NFIX gene function and related diseases
10.3760/cma.j.issn.1673-4408.2024.07.014
- VernacularTitle:NFIX基因功能及相关疾病研究进展
- Author:
Mingping LAN
1
;
Wenguang HU
Author Information
1. 电子科技大学医学院附属妇女儿童医院 成都市妇女儿童中心医院神经内科 611731
- Keywords:
NFIX gene;
Function;
Clinical features
- From:
International Journal of Pediatrics
2024;51(7):489-492
- CountryChina
- Language:Chinese
-
Abstract:
The nuclear factor I（NFI）family is a group of important transcription factors，consisting of four members：NFIA，NFIB，NFIC，and NFIX. The members of the NFI family are highly conserved in the N-terminal DNA binding and dimerization domain. The NFIX gene is expressed in many parts of the body，including the brain，prostate，muscles，skin，fat，and ovaries.It plays an important role in a variety of biological processes，including nervous system development，tumorigenesis，muscle and bone development，hematopoietic cell proliferation，and spermatogenesis.Currently，there are few studies and clinical reports on the NFIX gene in China，and its specific mechanism remains unclear，requiring further investigation. To draw the attention of clinicians and enhance the understanding of NFIX gene associated diseases，this article summarizes recent literature and reviews the function and clinical progress of the gene.
