Advances in the genetics of childhood obesity
10.3760/cma.j.issn.1673-4408.2024.07.006
- VernacularTitle:儿童肥胖症遗传学研究进展
- Author:
Ziwen ZHU
1
;
Lin YOU
;
Yuqing WANG
;
Jing QIAO
Author Information
1. 同济大学医学院，上海 200092
- Keywords:
Children;
Obesity;
Gene;
Genetic factor;
Treatment
- From:
International Journal of Pediatrics
2024;51(7):452-456
- CountryChina
- Language:Chinese
-
Abstract:
Childhood obesity is an escalating public health concern，with its prevalence rising year by year.This condition can lead to a series of metabolic disorders such as type 2 diabetes mellitus，hypertension，hyperlipidemia，and hyperuricemia.While various factors contribute to obesity，genetics plays a significant role，accounting for 40% to 70% of childhood obesity cases.Most of the identified loci harbor genes are involved in pathways affecting neuro-circuits that regulate appetite and satiety，insulin secretion and action，adipogenesis，and lipid metabolism.To date，using genome-wide association studies，over 1 100 obesity susceptibility loci have been identified，with notable examples being leptin，leptin receptor，and melanocortin-4 receptor gene.In this review，the correlation between genetic factors and childhood obesity and the possible mechanisms are elaborated to provide potential directions for its clinical management.
