Progress on the value of MMP-7 in the early diagnosis and prognosis evaluation of biliary atresia
10.3760/cma.j.issn.1673-4408.2024.06.005
- VernacularTitle:MMP-7对胆道闭锁早期诊断及预后评估价值的研究进展
- Author:
Shihui FU
1
;
Lingfen XU
Author Information
1. 中国医科大学附属盛京医院小儿消化内科，沈阳 110004
- Keywords:
Biliary atresia;
Matrix metalloproteinase-7;
Prognosis;
Early diagnosis
- From:
International Journal of Pediatrics
2024;51(6):377-381
- CountryChina
- Language:Chinese
-
Abstract:
Biliary atresia（BA）is the most common cause of liver disease in children leading to liver transplantation.Kasai operation is the main treatment method.Earlier diagnosis and younger age of operation can greatly improve the prognosis.Although the diagnosis and treatment of BA have been gradually improved in recent years，some patients still need liver transplantation or even die due to cirrhosis.There is still a lack of non-invasive prognostic evaluation methods.This article reviews the value of serum matrix metalloproteinase-7（MMP-7）level in the early diagnosis of biliary atresia，and discusses the relationship between MMP-7 level and the prognosis of children with biliary atresia，and how MMP-7 participates in the mechanism of the occurrence and development of biliary atresia，so as to provide reference for clinical diagnosis and treatment.
