Progress on inflammatory bowel disease associated with IL-10 signaling pathway deficiency
10.3760/cma.j.issn.1673-4408.2024.05.002
- VernacularTitle:IL-10信号通路缺陷相关的炎症性肠病研究进展
- Author:
Yiyao LI
1
;
Jian YANG
;
Xuemei ZHONG
Author Information
1. 北京大学首都儿科研究所教学医院 100020
- Keywords:
Inflammatory bowel disease;
Interleukin-10 receptor;
Gene deficiency;
Hematopoietic stem cell transplantation
- From:
International Journal of Pediatrics
2024;51(5):292-296
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-10（IL-10）is an important anti-inflammatory cytokine in human body，which is mainly secreted by macrophages，Th1 cells and Treg cells.It can inhibit pro-inflammatory mediators，promote anti-inflammatory mediators，inhibit antigen presentation，inhibit immune cell development and promote repair by binding to IL-10 receptors.In recent years，the incidence of IL-10 receptor mutation-related inflammatory bowel disease（IBD）gradually have increased.It shows a younger trend，and the clinical manifestations are not typical，the effect of traditional treatment is not good，which affect the diagnosis and treatment of the disease，as well as the prognosis.This article describes the IL-10 axis and its immune function in IBD，the epidemiology，clinical characteristics and treatment of inflammatory bowel disease related to IL-10 receptor mutation.
