Advances of acute kidney injury in premature infants
10.3760/cma.j.issn.1673-4408.2024.04.009
- VernacularTitle:早产儿急性肾损伤研究进展
- Author:
Xiaowan NIU
1
;
Yuxi LI
;
Li WANG
;
Yang WANG
;
Lili WANG
Author Information
1. 安徽医科大学第一附属医院儿科，合肥 230022
- Keywords:
Acute kidney injury;
Premature infant;
Gestational age;
Brith weight;
Organ
- From:
International Journal of Pediatrics
2024;51(4):255-259
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury（AKI）is one of the risk factors leading to death in premature infants.The incidence of AKI showed a upward trend year by year.The pathogenesis may be related to preterm birth with insufficient nephrons，prenatal inflammatory injury and urinary podocyte loss.The occurrence rate of AKI in premature infants increased with the decreasing of gestational age and birth weight.It should be emphasized that AKI in premature infants does not exist independently，but interacts with other organs，such as heart，lung，intestine，brain，and other organs.Moreover，the involvement of these organs may increase the risk of AKI，and so does bloodstream infections.Blood creatinine and urine volume can be used for clinical diagnosis and classification of AKI in premature infants.Glucocorticoids and caffeine can protect kidney in premature infants.Due to the lack of specificity in the treatment of AKI，fluid management and medication are important for the development of AKI.Renal replacement therapy，the common of which are peritoneal dialysis and continuous renal replacement therapy，can be used in severe AKI.
