Dental pulp stem cells express tendon markers under mechanical loading and are a potential cell source for tissue engineering of tendon-like tissue
- Author:
Chen YU-YING
1
;
He SHENG-TENG
;
Yan FU-HUA
;
Zhou PENG-FEI
;
Luo KAI
;
Zhang YAN-DING
;
Xiao YIN
;
Lin MIN-KUI
Author Information
- Keywords: dental pulp stem cells; in vivo model; mechanical loading; tendon engineering
- From: International Journal of Oral Science 2016;8(4):213-222
- CountryChina
- Language:Chinese
- Abstract: Postnatal mesenchymal stem cells have the capacity to differentiate into multiple cell lineages. This study explored the possibility of dental pulp stem cells (DPSCs) for potential application in tendon tissue engineering. The expression of tendon-related markers such as scleraxis, tenascin-C, tenomodulin, eye absent homologue 2, collagens I and VI was detected in dental pulp tissue. Interestingly, under mechanical stimulation, these tendon-related markers were significantly enhanced when DPSCs were seeded in aligned polyglycolic acid (PGA) fibre scaffolds. Furthermore, mature tendon-like tissue was formed after transplantation of DPSC-PGA constructs under mechanical loading conditions in a mouse model. This study demonstrates that DPSCs could be a potential stem cell source for tissue engineering of tendon-like tissue.
