Effect of hour administration and nursing on the predictability vomiting of lung cancer patients receiving the NP program
10.3760/cma.j.issn.1674-2907.2012.25.011
- VernacularTitle:长春瑞滨联合顺铂方案化疗时辰给药联合专项护理改善肺癌化疗患者预期性呕吐的效果
- Author:
Tian-Xin ZHAO
1
;
Rui MA
;
Hui WANG
;
Li JIANG
Author Information
1. 辽宁省肿瘤医院
- Keywords:
Nursing;
Lung cancer;
Antineeplastic combined chemotherapy protocols;
Hour administration;
Vomiting
- From:
Chinese Journal of Modern Nursing
2012;18(25):3012-3015
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of hour administration and care on the predictability vomiting of lung cancer patients receiving the NP program.Methods Totals of 79 cases that received NP chemotherapy program were randomly divided into chrono-chemotherapy group (n =40 ) and routine chemotherapy group (n =39).Chrono-chemotherapy group with PICC catheters received the vinorelbine (NVB) at the dose of 25 mg/(m2 · d),in the time of 17:00 to 03:00 and with the peak 21:00,d1 and d8 administration; and cisplatin (PDD) at the dose of 20 mg/( m2 · d),the administration time was 10:00～22:00 with 16:00 peak,d1-d3.The routine chemotherapy group with peripheral intravenous infusion received NVB at the dose of 25 mg/(m2 · d)with d1 and d8 administration,and PDD at 20 mg/(m2 · d) and administration in 9:00 ～ 13:00 and d1 ～ d3.Two groups received 2 to 4 cycles treatment with 21 days of one cycle.And received the routine care of lung cancer chemotherapy,while the chrono-chemotherapy group also be special cared such as strictly perform the hour clinical medication advice,maintain intravenous catheter patency,bedside shift and sleep care intervention and so on.Before the start of second cycle,both groups were treated with "ANY level indicators" and "disgusting questionnaire (NP) assessment.Results The ANY incidence of chromo-chemotherapy group (22.5％) was significantly less than that of routine chemotherapy group(58.97％ ).There were significant statistical different between the two group.In the chromo-chemotherapy group,the total score of nausea questionnaire (0.29 ± 0.13 vs 0.52 ± 0.19),body discomfort factor score (0.19 ± 0.07 vs 0.32 ± 0.11 ),gastrointestinal reaction factor score (0.27 ± 0.10 vs 0.45 ± 0.16 ),emotional pain factor score (0.17 ±0.06 vs 0.28 ±0.12),were.significantly lower than that of routine chemotherapy group,and the difference was statistically significant ( t =2.530,2.075,2.429,2.133 ; P ＜ 0.05 ).Conclusions NP program combines with hour administration and care can significantly reduce the ANY incidence and improve the level of ANY level indicators and NP questionnaire score of lung cancer patients.
