Research Progress and Application of Interfacing of Supercritical Fluid Chromatography and Mass Spectrometry
10.19756/j.issn.0253-3820.241215
- VernacularTitle:超临界流体色谱-质谱接口技术及应用进展
- Author:
Xue-Ge YANG
1
;
Huai-Yi CHEN
;
Xing-Yu PAN
;
Jin-Lei YANG
;
Fei TANG
;
Si-Chun ZHANG
Author Information
1. 清华大学精密仪器系 北京 100084
- Keywords:
Supercritical fluid chromatography;
Mass spectrometry;
Interface;
Review
- From:
Chinese Journal of Analytical Chemistry
2024;52(10):1465-1474
- CountryChina
- Language:Chinese
-
Abstract:
In the past few decades,supercritical fluid chromatography(SFC)as a supplement to liquid chromatography(LC)separation technology has attracted people's interest,especially in the combination of SFC and mass spectrometry(MS),which has shown important application prospects in metabolomics,lipidomics,and other fields.Compared to the interface of LC-MS,the interface of SFC-MS presents some unique challenges that require special solutions to be designed.This article categorizes and summarizes the existing interfaces used for SFC-MS,focuses on the impact of different interface designs on detection performance,provides the applicable characteristics of different types of interfaces,and finally briefly introduces the application progress of SFC-MS in different fields.
