Research Progress in Metal Element Probe Tagging Strategies
10.19756/j.issn.0253-3820.241257
- VernacularTitle:金属元素探针标记策略的研究进展
- Author:
Yue-Li HU
1
;
Cheng-Chao ZHANG
;
Yan LI
;
Yan-Xue WEI
;
Rui LIU
;
Yi LYU
Author Information
1. 四川大学化学学院分析测试中心,成都 610064
- Keywords:
Metal probe;
Tagging strategy;
Inductively coupled plasma mass spectrometry;
Biomolecule;
Review
- From:
Chinese Journal of Analytical Chemistry
2024;52(10):1457-1464
- CountryChina
- Language:Chinese
-
Abstract:
The metal element probe labeling strategy involves marking biomolecules with metal elements as signal-generating units and performing quantitative analysis of biomolecules through inductively coupled plasma mass spectrometry(ICP-MS).The combination of metal element labeling and ICP-MS technology offers significant advantages,including high sensitivity,high resolution,and low matrix effects,thereby expanding the approaches for quantitative analysis of biomolecules.This strategy has been widely applied in bioanalysis for broad purposes including disease diagnosis(or predication)and environmental regulation.Such an approach enables sensitive analysis and simultaneous detection of multiple components while overcoming interference from complex biological environments,presenting substantial application prospects.Over the past two decades,numerous research works have been reported in this area.Based on the abovementioned characteristics of the metal element labeling strategy,in this paper,the development of current labeling strategies based on metal element probe labeling were systematically reviewed,the advantages and disadvantages were discussed,the applications in high-sensitivity analysis and multiplex detection of biomolecules were reviewed,and an outlook on future development trends of this technology was provided.
