Recent Progress in Detection Techniques of Thyroglobulin
10.19756/j.issn.0253-3820.241277
- VernacularTitle:甲状腺球蛋白检测技术的研究进展
- Author:
Yue WU
1
;
Yong-Jie SHAN
;
Shou-Ji CAO
;
Shi-Qi JI
;
Bo-Wen CHEN
;
Xian-Ying MENG
;
Zhen-Xin WANG
Author Information
1. 连云港市第一人民医院甲状腺外科,连云港 222000
- Keywords:
Thyroglobulin;
Biosensors;
Thyroid disease;
Liquid biopsy;
Review
- From:
Chinese Journal of Analytical Chemistry
2024;52(9):1234-1243
- CountryChina
- Language:Chinese
-
Abstract:
Thyroglobulin(Tg)is a glycoprotein with large molecular weight,which is synthesized and secreted into the bloodstream by thyroid follicular cells.The concentration level of Tg in blood is one of the important biomarkers for diagnosis of thyroid diseases such as differentiated thyroid cancer(DTC),subacute thyroiditis,etc..Radioimmunoassay(RIA),immunoradiometric assay(IRMA),and immunochemiluminescence assay(ICMA)are the main clinical methods for detecting Tg.Recently,for meeting the requirement of detecting low concentration of Tg in blood after thyroid clearance surgery,researchers have developed various high-performance analysis methods for detecting Tg concentration in blood samples,providing new assays for thyroid disease screening and efficacy evaluation.This review summarized the analysis methods of Tg,especially the new progresses in the biosensors for monitoring low concentration of Tg in blood during the past five years.The current technical challenges of these methods in clinical applications were briefly discussed,which might provide useful information for developing new liquid biopsy methods of DTC.
