Comparison of two methods in pharmacokinetic blood specimen collection
10.3760/cma.j.issn.1674-2907.2012.20.034
- VernacularTitle:两种采血方法在药代动力学标本采集中的效果比较
- Author:
Yan-Fu SUN
1
;
Hong CHEN
;
Qing-Mei LI
;
Hong-Yan LI
Author Information
1. 吉林大学第一医院
- Keywords:
Pharmacokinetics;
Blood specimen collection;
Disposable venous blood-taking needle;
Venous indwelling needle
- From:
Chinese Journal of Modern Nursing
2012;18(20):2454-2456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find the scientific and safe blood specimen collection method by comparing two methods and to ensure the efficiency and quality of pharmacokinetic blood specimen collection.Methods 248 volunteers participating the clinical pharmacology experiment were randomly divided into control group and experimental group with 124 volunteers in each group.6 118 blood samples were collected in both groups.In the control group,blood was taken by intravenous catheter needle with 5 ml disposable sterile syringes.However,blood was collected with vacuum blood collection method that took blood by disposable venous blood-taking needle at the experimental group.Hemolysis,delay in collection time,insufficient quantities of specimen,contamination and needle injuries were compared in two groups.Results Hemolysis,delay in collection time,insufficient quantity of sample,contamination and needle injuries in the control group (304,92,1 530,765cases) were all significantly higher than the experimental group (25,15,122,21 cases),the differences were statistically significant ( x2 =243.136 2,55.900 0,1 387.346 4,750.324 7,respectively; P ＜ 0.01 ).Conclusions Disposable venous blood-taking needle is safe and highly effective in pharmacokinetic blood specimen collection.It is worthy to be utilized at the Phase Ⅰ clinical trial ward.
