Effect of preemptive analgesia on the postoperative pain and stress responses of patients with leg fracture
10.3760/cma.j.issn.1674-2907.2012.20.015
- VernacularTitle:超前镇痛对下肢骨折患者术后疼痛及应激反应的影响
- Author:
Li SU
1
;
Qun-Xi SHEN
;
Zhao-Hui LEI
;
Xu-Chun LI
;
Min LI
;
Jin-Xing YANG
Author Information
1. 广东省深圳市第二人民医院
- Keywords:
Pain;
Stress response;
Preemptive analgesia;
Celecoxib;
Parecoxib
- From:
Chinese Journal of Modern Nursing
2012;18(20):2404-2407
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of preemptive analgesia with celecoxib and parecoxib on the postoperative pain and stress responses of patients with leg fracture.Methods Eighty-two patients with leg fracture were randomly divided into experiment group( n =41 ) which received preemptive analgesia,and control group( n =41 ) which received routine analgesia.The visual analogue scale (VAS) was used to measured patients'pain at 4,8,12,24,48 h after operation.Levels of blood angiotensin-Ⅱ,cortisol and glucagon were assayed at various times as follows:pre-operation,end of surgery,postoperative 0,4,12,24 h,and adverse effects rate was observed in two groups.Results The postoperative 4,8,12,24 h score of experiment group were ( 3.54 ± 0.68),(4.08 ±0.97),(3.41 ± 0.59),respectively,lower than that of control group that were (4.63 ± 0.92),(5.38 ± 1.17),(4.48 ± 0.76 ),and the differences were statistically significant ( t =4.274 5,4.875 4,4.453 7,respectively ; P ＜0.05 ).While there was no significant difference detected in the VAS score of 24,48h between two groups (P ＞0.05).Levels of blood angiotensin- Ⅱ,cortisol and glucagon of patients' in 0,4,12 h of experiment group were significantly lower than that of the control group ( P ＜ 0.05 ),while no significant difference was found in the preoperation and post-operation 24 h between two groups( P ＞ 0.05 ).Adverse effects rate of experiment group was 7.3％ significantly lower than 31.7％ that of control group,the difference was statistically significant (x2 =7.77,P ＜0.01 ).There were 13 cases received the medicine of tramadol in experiment group and 32 cases in control group,and the difference was statistically significant (x2 =10.05,P ＜0.0 1 ).Conclusions Preemptive analgesia with celecoxib and parecoxib could decrease the postoperative pain of patients with leg fracture and reduce the adverse effects rate significantly and the stress reaction in postoperative period.
