Application Progress of RNA Fluorescence Aptamers in Biosensing and Imaging
10.19756/j.issn.0253-3820.221448
- VernacularTitle:RNA荧光适配体在生物传感与成像中的应用研究进展
- Author:
Xing-Chen QIU
1
,
2
;
Cun-Xia FAN
;
Rui BAI
;
Yu GU
;
Chang-Ming LI
;
Chun-Xian GUO
Author Information
1. 苏州科技大学 材料科学与工程学院,苏州 215009
2. 苏州科技大学 环境科学与工程学院,苏州 215009
- Keywords:
Fluorescent aptamers;
RNA;
Biosensing;
Bioimaging;
Review
- From:
Chinese Journal of Analytical Chemistry
2024;52(4):481-491
- CountryChina
- Language:Chinese
-
Abstract:
RNA fluorescence aptamers are RNA sequences that can specifically bind to non-toxic,cell permeable,and self-fluorescent target molecules and activate their luminescent properties.These aptamers provide powerful tools for biosensing and imaging researches due to their simple structure,easy synthesis,and easy transfection.This article summarized the characteristics and development history of various RNA fluorescent aptamers,including Malachite Green,Spinach,Broccoli,Mango,Corn,and Pepper family,as well as their corresponding fluorescent groups.The applications of RNA fluorescent aptamers were also reviewed from two aspects:extracellular detection and cell imaging.This review might provide guidance for labeling,detection and interactions of molecules from proof of concept and clinical assessment to practical clinical and biomedical applications.
