A study on the dynamic and static functional connectivity changes of amygdala subregions in patients with bilateral idiopathic tinnitus and hearing loss based on fMRI
10.16066/j.1672-7002.2024.09.007
- VernacularTitle:基于fMRI对双侧特发性耳鸣伴听力下降患者杏仁核亚区动态及静态功能连接变化的研究
- Author:
Yue SHI
1
;
Lanyue CHEN
;
Yi ZHANG
;
Xiaobo MA
;
Wei LI
;
Xiaoxia QU
;
Qian WANG
;
Yantao NIU
;
Zhaohui LIU
Author Information
1. 首都医科大学附属北京同仁医院放射科,北京 100730
- Keywords:
Tinnitus;
Hearing Loss;
Magnetic Resonance Imaging;
Amygdala;
dynamic functional connectivity;
functional magnetic resonance imaging
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2024;31(9):574-579
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the changes of static functional connectivity(sFC) and dynamic functional connectivity(dFC) of amygdala subregions in patients with bilateral idiopathic tinnitus and hearing loss(TINHL). METHODS The resting-state functional magnetic resonance imaging(fMRI) data of 30 patients with bilateral tinnitus and hearing loss and 37 normal controls(NCs) were collected to analyze the intensity changes of sFC and dFC in 8 subregions of amygdala and the whole brain in TINHL patients. RESULTS There were no significant differences in age,sex and education between the two groups. Compared with the NCs group,the sFC intensity of the right basolateral subregion and right cerebellar peduncle 1 region,the left basolateral subregion and left orbital medial frontal gyrus and left angular gyrus in TINHL group was significantly decreased. The dFC intensity of left amygdalostriatal subregion and left precuneus in TINHL group was increased,but the dFC intensity was reduced in the left basolateral subregion and right angular gyrus as well as between the right superficial subregion and right medial orbital of superior frontal gyrus. CONCLUSION Among the 8 subregions of amygdala,the bilateral basolateral subregions,the left amygdalostriatal subregion and the right superficial region shown abnormal functional connectivity with other regions of the brain,which are the important parts of emotional abnormalities in TINHL.
