Expression and clinical significance of serum miR-124-3p and miR-202-5p in patients with allergic rhinitis
10.16066/j.1672-7002.2024.08.008
- VernacularTitle:变应性鼻炎患者血清miR-124-3p和miR-202-5p的表达及临床意义
- Author:
Fengjie LIU
1
;
Buquan WANG
;
Chenggang MAO
Author Information
1. 荆州市中心医院耳鼻咽喉头颈外科,湖北 荆州 434020
- Keywords:
Rhinitis,Allergic;
MicroRNAs;
miR-124-3p;
miR-202-5p;
biomarkers
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2024;31(8):515-518
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE Exploring the expression levels of serum miR-124-3p and miR-202-5p levels in patients with allergic rhinitis(AR) and their clinical significance. METHODS One hundred and seventy-three patients with AR admitted to our hospital during the period from January 2022 to December 2022 were selected as the observation group,and another 63 healthy people who underwent physical examination in our hospital during the same period were selected as the control group. RESULTS In the control,mild,and severe groups,serum miR-124-3p(1.02±0.29 vs. 0.79±0.21 vs. 0.63±0.18) levels gradually decreased and miR-202-5p(1.01±0.25 vs. 1.39±0.29 vs. 1.62±0.33) levels gradually increased,with statistically significant differences between the two comparisons(P<0.05);Pearson correlation analysis showed a significant negative correlation between serum miR-124-3p levels and miR-202-5p levels in AR patients(r=-0.437,P<0.001);Serum miR-124-3p level[OR(95％CI)=0.651(0.508-0.835)],duration of symptom onset[OR(95％CI)=1.671(1.088-2.567)],asthma[OR(95％CI)=1.571(1.029-2.399)],and serum miR-202-5p level[OR(95％CI)=2.053(1.020-4.133)]were influential factors in patients with severe AR(P<0.05);the combined prediction of serum miR-124-3p and miR-202-5p was superior to the prediction of serum miR-124-3p(Z=2.385,P=0.017) and miR-202-5p(Z=2.466,P=0.014) alone. CONCLUSION Serum miR-124-3p is lowly expressed and miR-202-5p is highly expressed in AR patients,which is closely correlated with the severity of the patient's disease and is expected to be a potential biomarker.
