Analysis of pathogen distribution and drug sensitivity of otomycosis in Hangzhou
10.16066/j.1672-7002.2024.08.005
- VernacularTitle:杭州市外耳道真菌病病原菌分布及药物敏感性分析
- Author:
Danqing LIU
1
;
Xiao HE
;
Yanwen SUN
;
Xuxia TANG
Author Information
1. 浙江中医药大学附属第一医院(浙江省中医院)耳鼻咽喉科,浙江 杭州 310000
- Keywords:
Ear Canal;
Mycoses;
Drug Tolerance;
Antifungal Agents;
pathogen distribution
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2024;31(8):501-505
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the clinical characteristics,pathogen distribution and drug sensitivity of otomycosis in Hangzhou,in order to provide assistance for standardized treatment of otomycosis. METHODS A total of 115 cases of otomycosis with intact tympanic membranes,treated at our hospital from December 2022 to February 2024,were included in the study. Ear secretions were cultured,and pathogens were identified through morphological examination and mass spectrometry detection. Antifungal susceptibility testing was performed using a fungal susceptibility plate. All patients underwent ear canal cleaning under otoendoscopy combined with local drug perfusion. RESULTS The predominant pathogen in this region was Aspergillus terreus(60.8％). The susceptibility results showed that Aspergillus terreus is sensitive to posaconazole,voriconazole and itraconazole,and exhibits varying degrees of resistance to the other six drugs. The total effective rate of treatment in the 115 included patients reached 93％. CONCLUSION The main pathogen of otomycosis in this area is Aspergillus terreus,which is sensitive to triazole antifungal agents such as posaconazole,voriconazole,and itraconazole,which can be considered as the first choice for clinical treatment.
