Construction of motion sickness clinical model and diagnosis model based on blood index
10.16066/j.1672-7002.2024.07.006
- VernacularTitle:晕动病临床模型及基于血液指标诊断模型的构建
- Author:
Qiwei XIE
1
;
Jiali TU
;
Yaowen WANG
;
Weimin ZHANG
;
Hou SHI
;
Yan WANG
;
Hualin ZHU
Author Information
1. 宁波大学附属第一医院耳鼻咽喉头颈外科,浙江 宁波 315000
- Keywords:
Motion Sickness;
Pituitary Hormones;
Acetylcholine;
Gastrins;
5-hydroxytryptamine;
clinical model
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2024;31(7):435-439
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To construct a clinical model of motion sickness(MS),provide a relatively objective diagnostic model for MS research,and provide a basis for further clinical intervention of the disease.METHODS A total of 60 subjects were included and divided into experimental group and control group according to the presence or absence of MS.The MS clinical model was established using SRM-IV rotating chair.Peripheral blood was collected before and after acceleration exposure,and the contents of adrenocorticotropic hormone(ACTH),growth hormone(GH),prolactin(PRL),follicle stimulating hormone(FSH),luteinizing hormone(LH),thyroid stimulating hormone(TRH)and gastrin-17(G-17),acetylcholine(ACH)and 5-hydroxytryptamine(5-HT)were detected,Graybiel scale was used to evaluate the severity of MS.The correlation between MS symptoms and signs and peripheral blood indexes was analyzed by multiple linear regression,and the diagnostic model was established.construct a clinical model of MS and a diagnostic model based on blood parameters,so as to provide a reliable clinical model and an objective diagnostic model for MS research,and to provide a basis for further clinical intervention of the disease.RESULTS After acceleration exposure,the Graybiel scores,ACH,5-HT,ACTH,GH and PRL levels in peripheral blood of the experimental group were higher than those before exposure,and were significantly different from those of the control group(P<0.001).There was no significant difference in FSH,LH,TRH and G-17 between the two groups before and after acceleration exposure(P>0.05).Multi-index combined diagnostic model:Graybiel scores=-9.32+0.131×ACTH+0.055×ACH+0.041×5-HT.CONCLUSION The levels of ACH,5-HT,ACTH,GH and PRL increased during the onset of MS.The multi-index combined diagnosis model can provide a certain basis for the objective diagnosis of MS in clinical practice.
